MAPT and supranuclear palsy, progressive, 1: Notably, this region of tau has been characterized as a disordered fuzzy coat in all previously determined structures of tau fibrils, which includes the ex vivo fibrils from AD, CBD, PSP, GGT (globular glial tauopathy), and CTE patients as well as heparin-induced fibrils (8, –10, 16, 36).