In contrast to reversible fibrils, more favorable stabilization energy values are observed among ex vivo pathological fibrils such as human serum amyloid A (−34.4 kcal mol−1 chain−1, −0.64 kcal mol−1 residue−1) (4, 45), and the brain extracted tau fibrils from patients of AD, PiD, CTE, and CBD (Fig. 4C). This evidence concerns the gene MAPT and Alzheimer disease.