CFTR and cystic fibrosis: Hence, our group227 along with Bergougnoux et al.228 independently reported that 58 was not ableto increase F508del-CFTR maturation and chloride secretion in primaryairway epithelial cells from CF patients227 or in an ex vivo model of differentiated nasal cells obtained byscraping from CF patients.228 These differentobserved effects on the F508del-CFTR chloride channel could be explainedby alterations in the baseline chromatin state between primary bronchialepithelial cells and immortalized cell lines.