Furthermore, the alteration of deubiquitination process islikely to lead to dysregulation of other biological networks DUB-associated.Indeed, OTUB1 has recently emerged as an essential regulator of avariety of physiological processes, such as immune signaling and DNAdamage response, although its functions remain largely unclear.142 For that, elucidation of the mechanism of deubiquitinationof CFTR and better understanding the consequences on protein homeostasisare pivotal prior to consider DUBTACs or enDUBs as CF therapeuticstrategies. This evidence concerns the gene CFTR and cystic fibrosis.