In addition, the study suggested that 14-inducedmembrane trafficking of F508del-CFTR might be caused by the disruptionof mutant CFTR association with Hsc70 and CHIP, thus suppressing itsubiquitination and causing escape from the ERQC.95 However, the authors did not investigate the effect of 14 on other CFTR processing events, and after this initialinterest for 14 in CF, the group moved to study thissmall molecule for the development of new anticancer therapies.96 Here, HSPA8 is linked to cystic fibrosis.