Additionally, many proteostasis regulators have shown positivesecondary effects along with CFTR rescue activity, such as anti-inflammatoryor innate host defense stimulatory effects against invading bacteria.199,258 Those pleiotropic effects, if well-calibrated, could have a greatimpact on CF patients suffering from chronic lung infections and inflammation.With these considerations in place, the future of proteostasis regulatorscould be bright, new research projects involved in drug-like moleculesdiscovery will grow, and hopefully, this will be reflected into theclinic. The gene discussed is CFTR; the disease is Recurrent lower respiratory tract infections.