While the CFTR genotype correlates with pancreaticstatus, the correlations between the CFTR genotype and lung and gastrointestinalphenotypes are debated, with CF patients bearing the same genotypedisplaying heterogeneous phenotypes.256 Over the last 30 years, advances in specialized CF care and in theCF therapeutic landscape have increased the expectancy and qualityof life of people with CF. The gene discussed is CFTR; the disease is cystic fibrosis.