A higher proportion of patients with AD had elevated creatinine levels while a lower proportion had elevated prothrombin time (PT) compared with those without AD [creatinine above normal: 122/394 (30.96%) vs 1565/5894 (26.56%), P = 0.03; PT above normal: 4330/5894 (73.46%) vs 263/394 (66.75%), P = 0.004]. Here, F2 is linked to Alzheimer disease.