PRRX1 and atrial fibrillation: Recently, multiple genome-wide association studies and a meta-analysis consistently revealed that a common single nucleotide polymorphism (rs3903239) about 63 kb upstream of the PRRX1 gene, a top genetic variation at the locus of AF on chromosome 1q24, was associated with significantly increased risk of AF in both Europeans and Asians (Tucker et al., 2017; Wu et al., 2021).