CD80 and infection: To elucidate the immune response of cerebral cortex caused by IFN-γ, we evaluated the expression of inflammatory factors from polarized macrophages, and found that IL-23, the key factor in Th1-antigen-specific responses, as well as CD80 and CD86, the co-stimulatory factors for pro-immune responses, had a significantly down-regulated in the infected cerebellum and right ventricle, but preferentially higher expression in cerebral cortex post infection (Fig. 4F).