Two compelling studies described LRP1’s involvement in key AD pathologic events including Aβ clearance, amyloid precursor protein metabolism, matrix metalloproteinase 9 function, the pathogenic role of apolipoprotein E, modulation of glutamate receptor function, calcium homeostasis, and cellular TauO uptake and trans-synaptic spread [55, 57]. Here, APOE is linked to Alzheimer disease.