Two compelling studies described LRP1’s involvement in key AD pathologic events including Aβ clearance, amyloid precursor protein metabolism, matrix metalloproteinase 9 function, the pathogenic role of apolipoprotein E, modulation of glutamate receptor function, calcium homeostasis, and cellular TauO uptake and trans-synaptic spread [55, 57]. This evidence concerns the gene APP and Alzheimer disease.