FMR1 and fragile X syndrome: The mGluR signaling overactivation is one well‐established triggering factor of FXS pathomechanism, and we recently showed that mGluR diacylglycerol‐ (DAG) and phosphatidic (PA)‐dependent signaling upstream of local mRNA translation is disrupted by FMRP loss (Tabet et al, 2016a).