DGKk deregulation has been proposed to play a key role in FXS pathomechanism by altering DAG/PA signaling and by leading to an excess of DAG and lack of PA potentially responsible of excessive protein synthesis, a major molecular hallmark of FMRP defects (Tabet et al, 2016a, 2016b). The gene discussed is FMR1; the disease is fragile X syndrome.