APP and Alzheimer disease: Intracellular Abeta42 oligomers, which can be detected in brain homogenates of AD patients and typically range from di‐ to dodecamers, may thus represent predominant neurotoxic assemblies of the Abeta peptides (Shankar et al, 2008; Sokolow et al, 2012; Lesné et al, 2013; Chen et al, 2017; Ono, 2018).