The 3xTg mouse model expresses three transgenes: i) mutated Abeta precursor protein APP (APPSWE), ii) human four‐repeat tau P30lL mutation without amino terminal inserts (4R0N), and iii) human PSEN1 with M146V mutation, and is a widely used murine model of AD due to developing both main AD pathologies, namely extracellular Abeta depositions and tangle formations (Oddo et al, 2003). The gene discussed is APP; the disease is Alzheimer disease.