In addition to the ADAM22 variants identified in individuals with developmental and epileptic encephalopathy (DEE), we selected three homozygous missense ADAM22 variants (c.163C>T; p.(Leu55Phe), c.694C>T; p.(Arg232Cys), and c.2680G>A; p.(Val894Met) from the gnomAD database which contains sequencing data from presumably healthy individuals. The gene discussed is ADAM22; the disease is developmental and epileptic encephalopathy.