ADAM22 and encephalitis: In the case of LGI1 antibody encephalitis, the clinical symptoms depend on how much and where in the brain LGI1 autoantibodies are present to reduce the LGI1-ADAM22 protein complex, and therefore removal of LGI1 autoantibodies by immunotherapy could be mostly effective.40,41 Further studies are required to understand the mechanism for different clinical patterns of the three diseases.