TPR and Hutchinson-Gilford progeria syndrome: Most remarkably, progerin, a progeriatric isoform of Lamin A and causing the Hutchinson-Gilford progeria syndrome in humans, displaces Nup153 and TPR (the mammalian homologs of Nup60 and Mlp1/2) from the nuclear periphery (Balmus et al., 2018; Cobb et al., 2016; Kelley et al., 2011; Larrieu et al., 2018).