According to the OR, four parameters were high-risk factors for AKI in patients with PTB during anti-TB treatments: UM-microalbuminuria (OR = 3.038, 95%CI 1.168–7.904), URBC-hematuria (OR = 3.656, 95%CI 1.325–10.083), CYS-C (OR = 4.416, 95%CI 2.296–8.491), and CA-125 (OR = 3.93, 95%CI 1.436–10.756). The gene discussed is MUC16; the disease is acute kidney injury.