In particular, we show that the dCAM mouse line and the universally applicable AAV‐dCAS system can rescue PD motor behavior deficits by the direct conversion of endogenous striatal astrocytes into functional GABAergic neurons via CRISPRa‐mediated induction of the reprogramming factors Ascl1, Lmx1a, and Nr4a2. Here, ASCL1 is linked to Parkinson disease.