Zhang et al.42emphasized the cardioprotective effects of metformin against myocardial ischaemia/reperfusion (I/R) injury based on the pyroptosis mechanism. Mao et al. suggested that lncRNA KLF3‐AS1 derived from exosomes could ameliorate pyroptosis of cardiomyocytes and attenuate MI progression. Here, KLF3 is linked to myocardial infarction.