Moreover, TRIM proteins participate in multiple IBD‐related signalling pathways, including microbial recognition (e.g., NOD2, CARD9 and TLR2 pathways), immune cell differentiation (e.g., IL‐6/JAK/STAT3 pathway) and cytokine production (e.g., STING‐TBK1‐IRF3 pathway). Here, NOD2 is linked to inflammatory bowel disease.