Some tau mutations, e.g.,P301L and P301S, show drastic effects in patients and are used inmouse models of tauopathies.8,9 The conformational dynamicsof tau around P301 may play a direct role in modulating the aggregationof tau in disease,10−12 as studied also by molecular dynamics (MD) simulationsof tau fragments.12 Efforts to gain a clearerpicture of the local conformational dynamics of tau promise a deeperunderstanding of its roles in health and disease. Here, MAPT is linked to tauopathy.