MAPT and early-onset autosomal dominant Alzheimer disease: Intrinsically disorderedproteins (IDPs) are enriched in the proteomesof higher eukaryotes, where they perform essential functions.1−3 In healthy neurons, the paradigmatic IDP tau binds and stabilizesmicrotubules.1 In diseased neurons, tauloses the ability to bind to microtubules and forms the toxic aggregatesassociated with Alzheimer’s and other neurodegenerative diseases.2 Hyperphosphorylation of tau correlates with theprogression of Alzheimer’s disease.