One survey indicated that 80% of pediatricians had little-to-no knowledge of FPIES.2 These challenges often lead to misdiagnosis, unnecessary medical testing, frequent hospitalizations for acute reactions that were thought to be viral, and overall increased stress for FPIES families.2 Diagnosis is strictly clinical, and allergy testing, such as skin prick testing and specific IgE, is usually negative. The gene discussed is IGHE; the disease is allergic disease.