CD4 and allergic asthma: Moreover, LUT has the ability to regulate CD4+ T cell subsets in some cases, including acute lung injury, allograft rejection, allergic asthma, etc. [[31], [32], [33]] Unfortunately, like most flavonoids, LUT is prone to oxidation and degradation due to its highly unsaturated structure, and it is limited by its poor water solubility, low bioavailability and short half-life.