RAD51 and Friedreich ataxia: RAD51 gene itself (designated as FANCR) or many genes encoding the regulators of RAD51, such as BRCA1, PALB2, BRCA2, RAD51C, XRCC2, and RFWD3, are all mutated in FA individuals.10 In theory, TOPORS may fall into the category, given the importance of SUMOylation in RAD51 function.