Oral administration of losartan has also been shown to have beneficial effects in the musculoskeletal system such as in rheumatoid arthritis (RA) via up-regulation of angiotensin II receptor type 2 (AGT2R) and down-regulation of angiotensin II receptor type 1 (AGTR1) (Wang et al., 2013). This evidence concerns the gene AGTR1 and rheumatoid arthritis.