In the results of KEGG enrichment analysis (38), it was observed that some signaling pathways (e.g., PI3K-Akt signaling pathway, Foxo signaling pathway, Estrogen signaling pathway, MAPK signaling pathway, Th17 cell differentiation) are closely associated with the development and metastasis of chicken coccidioidomycosis. The gene discussed is AKT1; the disease is coccidioidomycosis.