Various epidemiological (Zhong et al., 2012; Ekblad et al., 2017; Kong et al., 2018), in vivo (Li et al., 2007; Wang Y. et al., 2014; Mehla et al., 2014; Zhang et al., 2017) and in vitro studies (Xie et al., 2002; Zhao et al., 2008; Gali et al., 2019) suggest insulin resistance and glucose imbalance as the underlying physiological mechanisms that link AD and T2D. The gene discussed is INS; the disease is Alzheimer disease.