MAPT and type 2 diabetes mellitus: In fact, Aβ40/42 and hyper-phosphorylated tau deposits were found in the pancreatic tissues of T2D patients where Aβ deposits were co-localized with IAPP in the affected islets of Langerhans (Miklossy et al., 2010; Martinez-Valbuena et al., 2019; Martinez-Valbuena et al., 2021).