In addition to IAPP and Aβ40 co-aggregation, the co-aggregation of other proteins such as Tau and α-Synuclein (Giasson, 2003), IAPP and α-Synuclein (Horvath and Wittung-Stafshede, 2016), IAPP and Tau-Fragment R3 (Arya et al., 2019), Aβ and α-Synuclein (Luo et al., 2016; Bhasne and Mukhopadhyay, 2018; Köppen et al., 2020) were reported which can elucidate the cross-talk of other protein misfolding diseases (Luo et al., 2016; Bharadwaj et al., 2017; Ren et al., 2019; Konstantoulea et al., 2021a). This evidence concerns the gene MAPT and proteostasis deficiencies.