IAPP and Alzheimer disease: However, recent findings highlight the role of Aβ and IAPP cross-interaction in mediating the cross-talk of AD and T2D at a protein level (Morales et al., 2009, 2013; Miklossy et al., 2010; Jackson et al., 2013; Martinez-Valbuena et al., 2019, 2021; Raimundo et al., 2020; Stanciu et al., 2020; Zhang et al., 2021).