In the context of breast and lung cancer, combined SX-682, an bioavailable small-molecule inhibitor of CXCR1 and CXCR2, and anti-PD-1/PD-L1 can achieve best tumor control in murine model (Sun Y. et al., 2019; Horn et al., 2020b). The gene discussed is CXCR1; the disease is lung cancer.