Recently, increased studies evidence that CXCL8 can induce the activation of Janus kinases and signal transducer and activator of transcription protein 3 (JAK/STAT3) signaling in both cancer and immune cells (Fu et al., 2015; Guo et al., 2017; Wu et al., 2019; Hu et al., 2020). This evidence concerns the gene CXCL8 and cancer.