Many excellent reviews demonstrate the role of CXCL8-CXCR1/2 axis in target therapy, chemotherapy and the prognostic role of plasma level of CXCL8 in cancer (Liu et al., 2016; Alfaro et al., 2017; Cheng et al., 2019; Fousek et al., 2021). Here, CXCL8 is linked to cancer.