CXCL8 and triple-negative breast carcinoma: As for directly targeting CXCL8, in triple-negative breast cancer (TNBC), HuMax-IL8, a fully human monoclonal antibody that inhibits CXCL8, can significantly reduce the infiltration of PMN-MDSCs to TME and enhance the efficacy of immunotherapy (Dominguez et al., 2017).