Previous reviews and many recent studies have illustrated that multiple cell types in TME can directly secret CXCL8, or regulate the expression of CXCL8 in cancer cells, or be regulated by CXCL8 derived from cancer cells to promote tumor invasion and migration (Zheng et al., 2018; Cheng et al., 2019; Nie et al., 2019; Fousek et al., 2021). This evidence concerns the gene CXCL8 and cancer.