TFRC and neoplasm: In addition, Peng Jiang (Jiang et al., 2018)developed TIDE (a computational method to model two primary mechanisms of tumor immune evasion), we found tumor associated macrophage M2 type (Fu et al., 2020) and TIDE score were negatively correlated with TFRC (Figures 10D,E), which further demonstrates the relationship between TFRC and immunotherapy.