To determine whether the ZEB1 and integrin α3 is regulated by STAT3 signaling in colon cancer cells, we used two independent siRNAs to knock down STAT3’s expression and then examined the expression of ZEB1, integrin α3 and GOLPH3 in HCT116 and HCT8 cells. The gene discussed is STAT3; the disease is malignant colon neoplasm.