EIF2A and familial pancreatic carcinoma: SLC6A14 implication in the mTOR pathway was previously described in pancreatic cancer cell lines (Coothankandaswamy et al., 2016) for which α-MT–mediated SLC6A14 blockade induces the decreased phosphorylation of proteins involved in the mTOR pathway including 4E-BP1, eIF-2α, and S6kinase.