The SLC6A14 gene has pleiotropic effects in pwCF (Ruffin et al., 2020), with several SLC6A14 single nucleotide polymorphisms (SNPs) being associated with different phenotypes such as meconium ileus (MI) occurrence, a severe neonatal intestinal obstruction (Sun et al., 2012), lung disease severity (Li et al., 2014; Corvol et al., 2015; Pereira et al., 2017), and age at first P. aeruginosa infection (Li et al., 2014; Pereira et al., 2017). Here, SLC6A14 is linked to intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.