Concerning the role of SLC6A14 in the intestine, it has been suggested that SLC6A14 involvement in MI susceptibility could be related to intestinal fluid secretion defect in CF, which was worsened in Slc6a14-KO CF mice carrying the major mutation F508del (Ahmadi et al., 2018). This evidence concerns the gene SLC6A14 and cystic fibrosis.