TGFB1 and neoplasm: Previous research has identified six molecular immune subtypes containing wound healing (C1), IFN-γ dominant (C2), inflammatory (C3), lymphocyte depletes (C4), immunologically quiet (C5), and TGF-β dominant (C6) subtypes, which were related to tumor molecular characterization and prognosis of patients (Thorsson et al., 2018).