However, of note, several recent studies with the aid of the next-generation sequencing and cell-free DNA detection found that LCNEC also comprised non-SCLC (NSCLC)-like subset, which may cause the individual response to different chemotherapy regimen; and the common driver mutations, including epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) rearrangements, etc., were rarely detected (4, 7). Here, ALK is linked to small cell lung carcinoma.