EGFR and large cell neuroendocrine carcinoma: However, of note, several recent studies with the aid of the next-generation sequencing and cell-free DNA detection found that LCNEC also comprised non-SCLC (NSCLC)-like subset, which may cause the individual response to different chemotherapy regimen; and the common driver mutations, including epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) rearrangements, etc., were rarely detected (4, 7).