Considering the preventive effect of IF, and RIF in particular as a unique diurnal TRE model (39), on the above-mentioned obesity-related indicators, and the principal role of FTO in controlling satiety, food intake, body fatness, and obesity risk (11, 13–16); the current work stemmed from the hypothesis that observing RIF will be associated with reduced expression of the FTO gene in fasting people with obesity. The gene discussed is FTO; the disease is Obesity.