SDC2 and colorectal carcinoma: The pooled diagnostic odds ratio (DOR) and area under curve (AUC) were 52.46 [95% <i>CI</i> (30.43-90.45)] and 0.94 [95% <i>CI</i> (0.92, 0.96)], respectively.<h4>Conclusions</h4>The ddPCR method was more sensitive and convenient to detect SDC2 gene methylation, and the pooled analysis showed that methylated SDC2 was a valuable biomarker for the non-invasive detection of CRC.