Our RNA-seq analysis also showed that the levels of IL17D, but not other IL17 family members (e.g., IL17A, IL17B, IL17C, and IL17F) was elevated in SLE-M placentas, while the IL-17 signaling pathway was enriched in both male and female placentas, supporting that IL-17 signaling pathway is actively involved in the dysregulation of placental immune response in SLE placentas. The gene discussed is IL17C; the disease is systemic lupus erythematosus.