MYCN and neoplasm: Previous studies have demonstrated the value of prognostic factors such as patients age, tumor stage using the International Neuroblastoma Staging System (INSS), tumor histopathology using the International Neuroblastoma Pathology Classification (INPC) system, DNA ploidy, cytogenetics such as MYCN amplification status and chromosome aberrations of 1p and 11q (1, 4, 5).