The fully adjusted regression model demonstrated that the increased SII scores were closely associated with higher levels of Scr elevation (β = 0.315, 95% CI: [0.206 to 0.424], P < 0.001), after adjusting age, sexw, diabetes, hypertension, eGFR, type and volume of contrast agent, EF, CRP, and medications (statin, furosemide injection and dopamine). The gene discussed is CRP; the disease is diabetes mellitus.