The upregulated expression of SMC1A, 4, 5, and 6 was strongly associated with an unfavorable RFS in PAAD patients with CD8+ T-cell enrichment (Figure 8A), and that of SMC1A, 2, 3, 5, and 6 was associated with poor RFS in PAAD patients with B-cell enrichment (Figure 8B). This evidence concerns the gene CD8A and pancreatic adenocarcinoma.