CAV1 and open-angle glaucoma: Importantly, genetic association studies reproducibly show that polymorphisms at the Cav1/Cav2 gene loci increase risk for POAG and ocular hypertension (Thorleifsson et al., 2010; Wiggs et al., 2011; van Koolwijk et al., 2012; Chen et al., 2014; Huang et al., 2014; Hysi et al., 2014; Loomis et al., 2014; Ozel et al., 2014; Kim et al., 2015).