HVCN1 and heart failure: The RNA-seq data indicated that HVCN1 was involved in cardiac pH homeostasis (Figure 7) and showed that HVCN1 regulated gene transcriptional networks controlling NOX signaling and CO2 homeostasis, suggesting a potential role of the HVCN1 channel in heart failure and cardiomyopathy, which are associated with abnormal expression of NOX and bicarbonate transporters.