Mutations in FAT4 and DCHS1 are associated with many cancers and multi system developmental defects such as Van Maldergem syndrome and Hennekam syndrome, characterized by craniofacial anomalies, intellectual dysfunction, digital contractures, hypoplastic kidneys, sternal and auditory defects (Cappello et al., 2013; Alders et al., 2014; Hou et al., 2016; Ma et al., 2016; Pilehchian Langroudi et al., 2017). The gene discussed is FAT4; the disease is Hennekam syndrome.