ITGAM and systemic lupus erythematosus: • Non-synonymous mutation in Mac-1 gene ITGAM causes “R77H” mutation in the β propeller domain. This results in decreased catch-bond formation with ligand under shear force ranging from 0.19 to 0.42 dyn/cm2 and is directly associated with SLE. Most significant difference was observed at 0.32 dyn/cm2 (Rosetti et al., 2015)