LAMB2 and rheumatoid arthritis: For example, we have discussed in the case of RA that MMP degrades collagen and that laminin frees the RGD peptide, which activates integrins, finally causing severe autoimmune disorder (Charo et al., 1990; Hoberg et al., 2006; Pankov and Yamada, 2002; Davis et al., 1990; Davis, 1992).