Vascular smooth muscle cell development, including 11 terms (36.7%), was the most important functional cluster, followed by lymph vessel development (13.3%), endothelial cell apoptotic process (6.7%), regulation of VEGFR signaling pathway (6.7%), etc. These findings suggest that the SRGs might regulate the stiffness of pituitary tumors by regulating the development, differentiation, and apoptosis of ECs and CAFs and related molecular pathways. This evidence concerns the gene KDR and pituitary tumor.