Interestingly, an alternatively spliced WSX-1 isoform (soluble WSX-1 or sWSX-1), which is expressed in neuronal cells was also found to convey an anti-AD activity, suggesting that CNTFR-α/soluble WSX-1/gp130 might serve as an alternative putative receptor for HN (Hashimoto et al., 2009b). This evidence concerns the gene IL27RA and Alzheimer disease.