It can additionally inhibit normal melanocyte growth, tumor growth, and metastasis of human uveal melanoma (Notting et al., 2007; Hsu et al., 2008; Na et al., 2009), but its dual role in cancer indicates that high BMP7 expression promotes the development of melanoma (Hsu et al., 2005; Rothhammer et al., 2005). This evidence concerns the gene BMP7 and uveal melanoma.