FUS and amyotrophic lateral sclerosis: Studies have reported some key features of ALS pathology, such as the involvement of mutated genes encoding RNA-binding proteins including the TARDBP (Sreedharan et al., 2008), fused in sarcoma (FUS) (Vance et al., 2009), and heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) (Kim et al., 2013).