Previous in vitro studies demonstrated that exosomes produced by adipose-derived MSCs could protect MN-like cells with ALS mutations from oxidative damage (Bonafede et al., 2016), play anti-apoptotic effect (Bonafede et al., 2019), and alleviate SOD1 aggregation and mitochondrial dysfunction (Lee M. et al., 2016). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.