In recent years, we established and characterized a Xenopus-based experimental model that recapitulates many of the developmental malformations characteristic of FAS following alcohol exposure, including microcephaly (Yelin et al., 2005; Yelin et al., 2007; Kot-Leibovich and Fainsod, 2009; Fainsod and Kot-Leibovich, 2018; Shabtai et al., 2018). The gene discussed is FAS; the disease is microcephaly.