CNTNAP2 and Pitt-Hopkins syndrome: For instance, the normal process of myelination is delayed in contactin-associated protein-like 2 (caspr2) knock out mice (Scott et al., 2019); besides, a mouse model of Pitt–Hopkins syndrome (PTHS), a syndromic form of ASD, showed reductions in mature oligodendrocyte numbers and myelination (Phan et al., 2020).