CCK-8, EdU, Transwell invasion and migration assay indicated that S1PR2 reversed the inhibition effects of miR-451a on cell proliferation, migration, and invasion in TPC-1 (Figures 6G,I,J) and IHH-4 (Figure 6H; Supplementary Figure S3) cells, indicating that the effects of miR-451a on thyroid cancer cell proliferation, migration, and invasion depended on S1PR2 suppression. This evidence concerns the gene S1PR2 and thyroid cancer.