As the homozygotes of CETP deficiency are apparently resistant for development of the fatal complication of Schistosomiasis japonica, i.e., hepatic granulomatosis and cirrhosis in the mouse model (Okumura-Noji et al., 2001), it is conceivable that this disease was one of the factors that caused high prevalence of the CETP gene mutations in the East Asia. Here, CETP is linked to Schistosomiasis japonica.