In the current study, we first revealed that NOP2 expression was upregulated in BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, SARC, STAD, THCA, and UCEC tissues, suggesting that NOP2 might act as an oncogene in pan-cancer. This evidence concerns the gene NOP2 and cancer.