A number of ALS-related genes encode RNA-binding proteins (RBPs) including TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and T-cell restricted intracellular antigen-1 (TIA-1) (Zhao et al., 2018; Kim et al., 2021). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.