Unlike wild-type, mutant SOD1 is identified in G3BP1- and TIA-1-positive SGs in the spinal cord tissue from SOD1G93A mice and SOD1 ALS patients (Gal et al., 2016; Mateju et al., 2017; Lee et al., 2020) and contributes to the impaired dynamics of SGs (Lee et al., 2020). Here, TIA1 is linked to amyotrophic lateral sclerosis.