MAPT and Alzheimer disease: Tau phosphorylation is closely associated AD pathological processing and many phosphorylated sites are known as Ser199-202-Thr 205 (AT8), T 231, and Ser 396-404 (Paired Helical Filaments) during NFT formation in AD pathology (Gu et al., 2013; Mondragón-Rodríguez et al., 2014).