MAPT and Alzheimer disease: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder involving the accumulation of amyloid-β (Aβ) plaques and tau protein-containing neurofibrillary tangles (NFTs) in conjunction with the acute and chronic inflammation leading to cognitive dysfunction (Lee et al., 2001; Spires-Jones et al., 2009; Zhang et al., 2021).