TRPM7 and familial primary hypomagnesemia: As a divalent cation channel, TRPM7 participates in the process of cellular uptake of Mg2+ in the external environment, TRPM7 is also involved in Mg2+ absorption, and the absence of TRPM7 kinase activity can lead to the same phenotype as hypomagnesemia, which indicates that Mg2+ can activate TRPM7 kinase activity to mediate downstream signaling pathways and regulate cell biological functions and activities (Zhao et al., 2019).