Figures 3A–C show that gene expression levels of MMP-12, MMP-13 and EMMPRIN were significantly higher in CCC and DCM myocardial tissue in comparison to samples from control group (P ≤0.05). The gene expression of MMP-3 and MMP-8 were undetectable in all samples tested. There were no significant differences in protein expression of MMP-3, MMP-8, MMP-12, MMP-13, and EMMPRIN between CCC, DCM and control samples (Figure 3D). The gene discussed is MMP8; the disease is familial dilated cardiomyopathy.