Here, we show for the first time, gene and protein expression, and also enzymatic activity of MMP-2, MMP-9 and gene and protein expression of their specific inhibitors TIMP 1, 2, 3, and 4 and EMMPRIN in myocardial tissue samples from CCC patients compared to DCM and from organ donors (control samples). Here, MMP2 is linked to familial dilated cardiomyopathy.