As shown in Figures 6A–C, MMP-9/TIMP-1 and MMP-9/TIMP-3 ratios were also increased in CCC heart tissue in comparison to DCM or control group (P ≤0.05); MMP9/TIMP2 and MMP-9/TIMP-4 ratio did not show any significant changes between the analyzed groups (Figure 6D). This evidence concerns the gene TIMP2 and familial dilated cardiomyopathy.