LGALS3 and Chagas disease: Pharmacological modulation of endogenous agents linked to fibrosis in CCC, like Galectin-3 (Souza et al., 2017) and microRNA-21 (Nonaka et al., 2021), or treatment with spironolactone (Ramires et al., 2006), colchicine (Fernandes et al., 2012) or bone marrow cells (Soares et al., 2011) promoted a significant reduction in cardiac fibrosis in rodent models of Chagas disease, showing that pathological remodeling is a promising therapeutic target in CCC.